Accordini et al.'s paper is a very well structures paper complying with the technical requirements of the research methodology and at the same time complying with ethical and confidential policies to run research with the selected participants. The literature review is sufficient to support the chosen title and enough to define a research track in order to generate empirical data to test the objectives. Technically the paper followed sophisticated modelling techniques with the necessary validation and reliability measurement tools. The results were very adequate to explain the outcomes. Results as manifested by the authors, "suggest that smoking during pregnancy and male puberty may increase the risk of asthma in the next generation, and that the effect of smoking during pregnancy may continue into a further generation within the maternal line. Our results provide further evidence on asthma recurrence across multiple generations." These results are highly significant [knowing the limitation of medical records and tests databases as explained in the paper] and strongly support the design and implementation of awareness campaigns though the paper did not suggest any recommendations at the policy level.