OVERVIEW AND GENERAL RECOMMENDATION The submission ‘‘Cupuassu (Theobroma grandiflorum) fruit development: key 2 genes involved in primary metabolism and stress response’’ reports on the expression and interactomics analyses of some previously selected genes involved in fruit quality and/or resistance of Cupuassu to Moniliophthora perniciosa, the causative agent of the witches’ broom disease. better understand the molecular and physiological mechanisms associated with these plant processes. Considering that the products from this species holds great potential at international level owing to the various uses of its fruit pulp and seeds, the current is on a topic of importance publishable in AGRONOMY. I must admit that I found the paper to be scientifically well described and succinctly presented. I believe minor revisions considering the following comments is sufficient for me to recommend it for publication.
SPECIFIC COMMENTS ABSTRACT L19: Here >> In this study. L22: We showed that >> It was found out that. This is because I recognize that the word ‘‘showed’’ appeared twice in the same line. L23-25: Delete ‘‘that’’ indicated several times in these lines. I suggest numbering the results of the study to avoid this word. KEYWORDS I suggest adding Interactomics and Signal transduction as author-suggested indexing keywords. INTRODUCTION L37: The cited study is too old. I suggest citing the recent report by Barbalho et al. (2022) which emphasizes this same fact in the Amazon region. Barbalho et al. Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules. Pharmaceutics 2022, 14, 207. https://doi.org/10.3390/pharmaceutics14010207 L36-37: The authors could summarize the uses of the different parts of Cupuassu, before being specific to the seeds. MATERIALS AND METHODS L90: Material >> Materials L148: the species closest to T. grandiflorum >> a species that is closest to T. grandiflorum.