This research holds promise for designing hydrogel systems based on drug release. This work is straightforward yet engaging and can be recommended for publication after major revisions.
1. The authors need to work on the abbreviations, which should be described in the first description, particularly in the abstract and introduction sections.
2. The authors need to supplement the introduction sections with the following: "What is the intentional route of administration of this hydrogel system, and how will it be beneficial over conventional medication, as mentioned, for targeted colonic drug delivery?"
3. Provide the enzyme information that reports the metabolism/biodegradation of this polymer structure.
4. Chitosan is a cationic polymer and can form a polyelectrolyte complexes with anionic polymers such as CMC and alginate; authors need to be double-check if UV crosslinking will beneficial.
5. Section 2.2, Hydrogel synthesis, : provide how much mMol have been used.
6. Fig.1. Authors should use contrast colours, and need to improove the figure quality.
7. Section 2.3. DMSO solution has been used; authors need to clarify if it needs to be removed. For drug delivery, removing organic solvents is strongly recommended for applications.
8. The authors should use the p-value to discuss the important group comparisons throughout the manuscript.
9. Major experiment: An in vitro biological assay or in vivo study is strongly recommended to prove this system's significance for biomedical applications over conventional medication.
10. Last but not least, a thorough formatting and language edit/review is required.