GENERAL COMMENTS

In the second paragraph of the introduction, the statement is made that the shorter application for NIH "...consequently reduced the burden on applicants." This is a point that is sometimes debated by NIH investigators. More information yields better informed reviewers who may not have the exact expertise needed for adequate peer review with less information. One can accurately state that the INTENT was to reduce the burden to applicants and peer reviewers, but it is unclear if this is the actual result.

Please correct citation 15 to Shambrook JF rather than Shambrook JP.

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