• There are several studies in literature reporting the anti-cancer effects of the two compounds, the only new addition in this work is the effect of cisplatin in combination with the two drugs. • The authors show a decrease in body weights after treatment with the two drugs. What is the reason for decrease in comparison to untreated where there is an increase in body weight? • Most of the anti-tumor drugs are known to cause regression in tumors by an apoptotic mechanism. Only gene expression of Bax, Bcl-2 and caspase-3 are shown which is an expected outcome. The authors should dwell more into the mechanism and also demonstrate the effect on protein expression of these markers. Caspase-3 enzyme activity is also missing. • The data on the anti-oxidant parameters is not very convincing. In all the parameters tested there appears to be a marginal difference after treatment with the two compounds or in combination with cisplatin. Probably the role of the Nrf2 transcription factor and its downstream enzymes may give more insight.

Conflicts of interest

Do you have any conflicts of interest here? No