The study is innovative in studying suPAR through immunohistochemistry in psoriatic patients.
However, some issues are needed to be addressed:
- In view of the limitations of the study, it is hard to include MS in the title. It would be appropriate to say: SuPAR, a potential inflammatory mediator in psoriasis pathogenesis.

• The introduction is redundant with long citation from a single reference (5).

• In Methods: References for the PASI, BMI, Fasting insulin, ESR and CRP categorization should be added.

In Results: Page 7, line 23: individuals should replace patients as 30 of them were healthy control.
- The variables are very crowded to be included in a single table. So, it would be better to be divided into 2 table e.g. Cases and controls' variables in one table and psoriasis immunohistochemistery results in another one.

In discussion:
- The authors started by Paradoxical to prior studies; however, to the best of my knowledge they are the first to study uPAR staining. in psoriasis.
- Two references related to the study could add to the discussion: the first evaluate the suPAR in the semen of psoriatic patients and the second evaluate ADA and other inflammatory mediators in psoriasis respectively.
1- Caldarola G, Milardi D, Grande G, Quercia A, Baroni S, Morelli R. et al. Untreated Psoriasis Impairs Male Fertility: A Case-Control Study. Dermatology. 2017;233(2-3):170-174. doi: 10.1159/000471849.
2- Yousry M M , Moustafa AE , Ehsan M A , Rasha A El. Evaluation of Serum Adenosine Deaminase and Inflammatory Markers in Psoriatic Patients. Indian J Dermatol. 2019;64(3):207-212. doi: 10.4103/ijd.IJD_420_17.

In references: The authors should abide to the styling of the journal regarding journal titles' abbreviations.

Thanks to the authors
You have completely addressed all the suggested issues in a satisfactory manner.