Content of review 1, reviewed on August 23, 2018
The last hundred years have witnessed the death of millions of humans to Cancer [all its types and branches]. Cancer is one of the fiercest enemies and agent of death all over the world. The world health organization (WHO) estimates that 84 million people would die of cancer between 2005 and 2015. Consequently, thousands of researchers around the globe working hard in an effort to develop as many approaches to mitigate / reduce / or even nullify the threat caused by cancer. Chemotherapy is an important option in modern cancer treatment, and many clinically available anticancer drugs are currently used to treat some types of leukemia, lymphoma and solid tumors. However, according to Behzad et al. (2014, p. 199) [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977071/], "the introduction of active agents derived from nature into the cancer armamentarium has changed the natural history of many types of human cancer. Statistics indicated that a half part of anticancer drugs approved internationally between 1940(s) and 2006 was either natural products or their derivatives. It is this aforementioned effort that is driving more scientists to identify, develop and create anticancer drugs. Ahmed E. Fazary et al.'s article goes along this track. According to the authors, "Platinum(II) and vanadium(V) solid binary and ternary complexes involving naringin, a flavanone glycoside in found in grapefruit, and some phenolic acids were synthesized and fully characterized using detailed structural and spectroscopic analysis techniques such as IR, NMR, and SEM techniques". Naringin and antioxidant phenolates have been the focus of attention in recent years due to their potential applications in biological, industrial, and medicinal processes. This paper follows a strict scientific research process with high standards to carry out the multidimensional biological, chemical and physichochemical analysis of naringin and phenolic bioligands. Top of the line bio-technological equipment and tools were utilized to guarantee valid and reliable results. The researchers were meticulous, careful and accountable for their work. The findings include several dimensional outcomes being strictly chemical structure, physical characteristics, and biological behavior. Of special interest here is what the authors contend, " Naringin is known to be a main constituent of bioflavonoids found in several fruits so that one can merely take it as food additives. The present biological results suggested that naringin and its metal complexes are a useful compounds having antioxidant activity. However, it has a less cytotoxic activity in comparison with its binary and mixed ligand complexes." The outcomes bring to our attention the efforts to bring new compounds with higher cytotoxicity against cancer cells. Worth mentioning here, that the authors tested their compounds versus "HepG2 (human hepatocellular carcinoma), MCF-7 (human breast adenocarcinoma), and HCT116 (human colorectal carcinoma) tumor cell lines. The authors are commended for their efforts and their eagerness to share their findings with the scientific community at large and with readers who are interested about the evolution of new compounds in the war against cancer.
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© 2018 the Reviewer (CC BY 4.0).
References
E., F. A., Yi-Hsu, J., S., A. A., Z., B. M., Y., A. M., A., A. M., A., S. K., I., E. S. E., F., F. K., M., A. H. S. 2017. Platinum and vanadate Bioactive Complexes of Glycoside Naringin and Phenolates. Open Chemistry, 15(1).