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The objective of the present study was to determine antioxidant activities, DNA protective activities, cytotoxic effects, oxidative stress status and phenolic content of Trametes gibbosa (Pers.) Fr., Fomes fomentarius (L.) Fr., Fuscoporia torulosa (Pers.) T. Wagner and M. Fisch., Daedalea quercina (L.) Pers., Inonotus hispidus (Bull.) P. Karst. and Trichaptum biforme (Fr.) Ryvarden mushrooms. DPPH method was used to determine the antioxidant activities. DNA protective activity was determined with pBR 322 supercoil DNA. To determine the cytotoxic effects, the effects of extracts on A549 cell line were tested. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were determined. Phenolic content and other phytochemicals were screened with HPLC device. It was determined that antioxidant activities increased as the concentration of mushroom ethanol extracts increased. The highest activity was observed in I. hispidus EtOH extract, and the lowest activity was observed in T. gibbosa EtOH extract. It was determined that all mushroom ethanol extracts exhibited DNA protective effects. The highest cytotoxic effect on A549 cells was observed with D. quercina ethanol extract. No cytotoxic effect was observed in I. hispidus and F. torulosa species. In conclusion, it was determined that the macro-mushrooms scrutinized in the study could be used in medicinal, pharmacological, nutrition and environmental protection applications due to their strong antioxidant, DNA protective and cytotoxic activities.


Bal, Celal;  Akgul, Hasan;  Sevindik, Mustafa;  Akata, Ilgaz;  Yumrutas, Onder

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