A. General comments:
The authors’ work put forward in the paper is of significant value for publication. The synthetic chemistry is interesting and the authors have provided a thorough discussion of the findings. Recommend publication with some minor revisions noted below.
B. Strengths and weaknesses:
Strengths: solid synthetic work and cytotoxicity studies conducted.
a. All synthesized molecules must be characterized fully. Several molecules do not have 13C NMR data provided.
b. The manuscript’s readability suffers due to substantial grammatical, spelling, word usage errors and incorrect punctuation. These issues are throughout the entire manuscript. I am including an edited manuscript (suggested corrected parts are highlighted in yellow) that addresses many of these issues to make the manuscript close to publication-ready.
c. Figure, Table and Schema formatting not in accord with AJOC standards. I have provided corrections in the suggested corrected manuscript.
C. Suggestions for improvement:
Provide 13C NMR data in the experimental section for all molecules prepared which do not presently contain this data.
That the authors adopt the recommended changes indicated in the edited manuscript and resubmit a revised version that includes these changes and the 13C NMR data.