University of Florida
About University of Florida
The University of Florida (commonly referred to as Florida or UF) is an American public land-grant, sea-grant, and space-grant research university located on a 2,000-acre (8.1 km2) campus in North Central Florida. It is a senior member of the State University System of Florida and traces its historical origins to 1853, and has operated continuously on its present Gainesville campus since September 1906.
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Dr. Chan has lifelong interests in human autoantibodies during his postdoctoral training at the Scripps Research Institute, La Jolla. His lab has been highly successful in using autoimmune antibodies to identify and clone a number of interesting self-antigens. These include SS-B/La; Ro52/TRIM21; the ribosomal RNA transcription factor NOR90/hUBF; p80-coilin of the Cajal body; coiled-coil-rich Golgi proteins known as golgins; and GW182, a marker for cytoplasmic foci GW bodies. A new area is the identification of novel rod/ring structures, that are targets of autoantibodies in patients with hepatitis C infection and undergone interferon/ribavirin therapy. These structures are observed in conditions requiring increased GTP/CTP biosynthesis in all mammalian cells examined to date. Since 1999, he has served on the Autoantibody Standardization Committee and currently serving as Chairman (2015-2018). He also serves as coordinator for the International Consensus on Antinuclear antibody Patterns (ICAP) initiative together with Luis E. C. Andrade since 2014. His lab is currently active on microRNA research in innate immunity, autoimmune diseases, and oral cancer.
Islam Y. Elgendy is a Cardiology/Interventional Cardiology fellow at the University of Florida College of Medicine. His major clinical and research interests include the impact of various interventions and pharmacotherapies on the outcomes of patients with coronary artery disease, acute coronary syndromes and acute ischemic stroke. My research focuses on clinical research related to meta-analysis, epidemiology as well as outcomes research in acute coronary syndromes, acute ischemic stroke, and heart disease in women. I have published over 90 manuscripts in peer review journals such as Journal of the American College of Cardiology, JACC: Cardiovascular Interventions, Circulation: Cardiovascular Interventions, Annals of Thoracic Surgery, Hypertension, American Journal of Medicine, Catheterization and Cardiovascular Interventions, and others.
Expertise in induced pluripotent stem cell (iPSC) biology. Generation of iPSCs by small molecules (chemical based reprogramming), lenti, retro, sendai, mRNA and protein based reprogramming. Directed differentiation of iPSCs and ESCs (human, mouse, rat) into neurons (oligodendrocytes, DA neurons), cardiomyocytes, pancreatic beta cells, CD4/CD8 T-cells. Nano toxicological assessments of engineered nanoparticles using ESCs as a model system. 3D cell culture of cancer stem cells, iPSCs, ESCs, spheroid and organoid formation. DNA damage responses in ESCs.
I am primarily interested in the determinism of the spatial distributions of animal species, from a fine scale (movement models) to a large scale (distribution in the landscape) in relation to the habitat and other species. My work lies on a strong theoretical and methodological basis using the concept of ecological niche, and allows applied achievements in the context of animal population management, as well as basic developments at the intersection of evolutionary ecology and behavioural ecology. My main study species are large mammals (notably those involved in predator-prey systems) and tetrapods in general, including lynx in Norway, caribou in Quebec, and wood stork in Florida.