University of East Anglia
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Journal Editors at University of East Anglia
Reviewers from University of East Anglia
I was appointed as an academic surgeon to the University of East Anglia in 2010, funded in part by the Anthony Long Trust. As Professor of Rhinology & Olfactology at UEA, I am the chief investigator of a number of research projects including the chronic rhinosinusitis epidemiology study (CRES), that ran nationally to understand risk factors that contribute to rhinosinusitis. Other research roles include being ENT Lead for the Eastern Clinical Research Network and Chair of the British Rhinological Society Research Group where I have helped to shape the national research priorities for nose and sinuses diseases.
I am a graduate of Leicester University Medical School and completed my basic surgical training in the University Hospitals of Leicester before undertaking a period of research into developing apparatus for testing the sense of smell, which culminated in my MD Thesis. My specialist training was completed in East Anglia, during which time I spent a year at the St Paul’s Sinus Centre in Vancouver, Canada learning advanced skills in endoscopic sinus surgery for inflammatory diseases of the nose and sinuses as well as tumours of the sinuses and anterior skull base. My main clinical interests include the medical and surgical treatment of chronic rhinosinusitis, allergic fungal rhinosinusitis and other sino-nasal disorders. I established the first dedicated ENT image guided sinus surgery facility in East Anglia and now run a regular sinus surgery course at UEA.
I have also spent time at the Dresden University Smell & Taste Clinic learning techniques for assessing and researching the sense of smell and am now the Director of the first British Smell & Taste Clinic and receive referrals from around the UK. This provides the opportunity to research the impact of olfactory disorders on sufferers. Furthermore I have helped advise on the establishment of a patient support charity, Fifth Sense, which now has some 2500 members around the UK.
Lee's research focuses on supporting older people to eat and drink well, and she is a dietitian, nutritionist and systematic reviewer. Her current research (initiated during her National Institute for Health Research Career Development Fellowship) is on preventing and identifying dehydration in older people living in residential (long-term) care. See http://driestudy.appspot.com/ for details of the DRIE (Dehydration Recognition In our Elders) Study.
Lee has a long term interest in the nutrition and hydration of older people. She is an expert systematic reviewer and has developed and managed many systematic reviews. Lee has been an editor for the Cochrane Heart Group for 14 years, was an editor of the Cochrane Oral Health Group for 5 years, and regularly referees systematic reviews for top medical and nutrition journals.
Lee is a Reader in Research Synthesis, Nutrition & Hydration in the Norwich Medical School at the University of East Anglia and has a BSc in Biochemistry, PhD (University of Manchester) and current dietetic registration. She worked as a dietitian in the National Health Service for ten years, with extensive experience of community health promotion and cardiovascular health. Lee moved to research in 2000 and has since published over 80 peer-reviewed publications, mainly in the areas of dehydration and nutrition of older people and the effects of dietary change on health. Her publications have been cited almost 3000 times (with an average citation per publication of over 33, and h-index of 29).
Lee is a member of the World Health Organization Nutrition Guidance Expert Advisory Group (NUGAG) on Diet and Health, which has recently produced guidance on sodium and potassium intakes. As well as being a Cochrane editor, she is an editor of Quality in Ageing and Older Adults, was awarded Ibex Award by British Dietetic Association (2005), and was a member of the National Institute for Clinical Excellence (NICE) Partners Council.
Bacteria can become resistant to antibiotics through a number of different mechanisms. These include intrinsic mechanism that all members of the bacterial species posses and that they switch on or ‘ramp up’ when exposed to antibiotics, and mechanisms that the bacteria acquire from external sources that can then be exchanged between bacteria. My work centres on understanding which mechanisms bacteria are using to become resistant to antibiotics, and how these are evolving and being transferred in bacterial populations. An example of current work is investigating the effect of non-antibiotic drugs, such as cancer chemotherapies, on promoting antibiotic resistance. Many drugs used in healthcare coincidently have antibacterial properties, and therefore bacteria develop resistance against these. However, in doing so, some bacteria can become more resistant to antibiotics at the same time, even without having been exposed to any antibiotics. This ‘cross-resistance’, where exposure to one drug (e.g. a cancer chemotherapy) causes resistance to a different drug (e.g. an antibiotic) is not well understood despite its potential to have a major impact on the evolution and spread of antibiotic resistance. By understanding how different drugs cause cross-resistance to antibiotics we will gain a more holistic view of antibiotic resistance that can be exploited in the design and development of new drugs, and in the management and use of existing drugs.