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Dr. Harirforoosh is an Associate Professor in the Department of Pharmaceutical Sciences at East Tennessee State University, Gatton College of Pharmacy. He received his Doctor of Pharmacy from Tehran University of Medical Sciences (Tehran, Iran) in 1991, and his PhD in Pharmaceutical Sciences (Pharmacokinetics) in 2005 from the University of Alberta (Edmonton, Canada). He served as a research assistant and a postdoctoral fellow at the Pulmonary Research Group, University of Alberta from June 2005 to May 2006. He is also a registered pharmacist with the Alberta College of Pharmacists. Dr. Harirforoosh serves on the editorial boards of the journals of Clinical Pharmacokinetics, European Journal of Drug Metabolism and Pharmacokinetics, Heliyon, and Journal of Integrative Nephrology and Andrology. He has also served as a peer reviewer for numerous scientific journals and as a research advisor for a significant number of PhD, PharmD, MPH, and undergraduate students. Dr. Harirforoosh is a member of the American Association of Pharmaceutical Scientists, American College of Clinical Pharmacology, American Society for Clinical Pharmacology and Therapeutics, and American Association of Colleges of Pharmacy.
According to the National Health and Nutrition Examination Survey two-thirds of U.S. adults are either overweight or obese. The estimated direct costs associated with obesity, metabolic syndrome, and Type 2 Diabetes is approaching 100 billion dollars annually.
My research goals are to examine the changes in metabolism that occur in the presence of obesity and/or Type 2 Diabetes and to develop clinical biomarkers and potential therapeutic targets. Currently, my lab focuses on a family of secreted proteins termed C1q TNF-Related Proteins (CTRPs). CTRPs are a novel family of secreted proteins, which circulate in the blood stream. Many members of the CTRP family are adipokines, meaning secreted from adipose tissue, but the CTRP family includes proteins that are secreted from a variety of tissues. For example, CTRP15 (also called myonectin) is secreted primarily from skeletal muscle and therefore is called a myokine.
My research focuses on characterizing the functions of these proteins, using molecular, biochemical, in vitro and in vivo approaches. Much of my initial work demonstrates that the CTRP family of proteins contribute metabolism and are dysregulated with obesity. However, the functions of the CTRP protein family are still actively being investigated.
David Cluck, PharmD is an Associate Professor in the Department of Pharmacy Practice at East Tennessee State University Gatton College of Pharmacy. He joined the college after completing a specialty residency in infectious diseases at Wake Forest Baptist Medical Center. Dr. Cluck maintains a clinical pharmacy practice in infectious diseases at Johnston Memorial Hospital as well as a weekly outpatient HIV clinic with the ETSU HIV Center of Excellence. He is an active member of ACCP, IDSA, and AAHIVM.