University of British Columbia
About University of British Columbia
The University of British Columbia is a global centre for research and teaching, consistently ranked among the 40 best universities in the world. Since 1915, UBC’s West Coast spirit has embraced innovation and challenged the status quo. Its entrepreneurial perspective encourages students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world.
5th in Canada
2nd in Canada
2nd in Canada
16th in Canada
Journal Editors at University of British Columbia
Reviewers from University of British Columbia
An evolutionary biologists interested on interplay between genetics, selection and environmental variation from level of genes and individuals to populations and species. Particularly intrigued by relative roles of selection, drift and environmental variation contributing to population differentiation. Fond of natural history and biogeography, especially those of vertebrates.
My review profile is more or less complete from early 2015 onwards (review record before that fragmented and incomplete).
My primary research focus is to understand the neural substrates of motor learning in healthy individuals and patients after stroke. This work utilizes cutting-edge neuroimaging techniques to evaluate both human brain anatomy (structure) and physiology (function). It remains unclear how the brain optimally recovers from neurologic insult and, therefore, rehabilitation strategies aimed at ameliorating functional impairments following injury are currently suboptimal. My work aims to understand how best to measure brain recovery after injury and how best to stimulate optimal restoration of function.
Wendy V. Norman MD, CCFP, FCFP, DTM&H, MHSc CIHR-PHAC Chair, Family Planning Public Health Research; Associate Professor, Dept of Family Practice; Associate Member, School of Population & Public Health, and Dept Obstetrics & Gynecology; Faculty of Medicine, University of British Columbia
I am a microbiologist engaged in basic research mastering microbial genetics and biochemistry of microorganisms. My research focuses on translational research of bacterial pathogens aiming at anti microbial drug development. My first major contribution to the field of Tuberculosis (TB) research was the identification of the “Eukaryotic – like” protein kinases of Mycobacterium tuberculosis, a new family of proteins which play a role in the bacterial adaptive gene expression and cross-talk with the infected human macrophages. This discovery opened a new field of research into signaling elements of M. tuberculosis and gained my laboratory leading recognition in mycobacterial signal transduction research. In collaboration with industry my group has shown that small molecules targeted against one of these kinases can block the growth of M. tuberculosis within macrophages and thus can be used as novel anti-TB therapy. Using proteomics and global kinome analysis my team showed that mycobacterial infection triggers a signaling cascade leading to activation of stress-activated protein kinases. More recently, our research identified an M. tuberculosis Phosphatase, PtpA, which inhibits macrophage “normal” response to infection by targeting host signaling proteins and the macrophage acidification machinery. To show that we used gene knock-out and substrate trapping technologies and a novel technique, neutralizing PtpA in vivo by expressing intracellular single chain antibodies within the TB infected macrophage. My research into nitric oxide reveal its role in activating M. tuberculosis kinases and identified the thiol-based mechanism used by mycobacteria to protect themselves from nitric oxide damage. We have translated our basic research into commercialization by licensing his technologies to various companies.