The research activity is aimed at the development and validation of chromatographic methods (according to international guidelines, ICH) for the qualitative and quantitative determination of biologically active molecules in human and animal (eg. Serum, plasma, bile, liver tissue, hypothalamus, kidney, feces, urine), cosmetics, food, and environmental complex matrices. It provides, in addition, to the study of all processes related to pre-analytical stages such as sampling, extraction and purification, separation, enrichment, even the application of conventional and hyphenated analytical methods for the accurate, sensitive and selective determination of biologically active molecules. These procedures have been applied to different analytes: glucosamine , 5-amino-salicylic acid , natural or synthetic bile acids , anti-inflammatory [22, 23, 37], drugs association [47, 59, 62, 77] and fluoroquinolones [25, 49, 53], secondary metabolites from plant and food supplements [6, 7, 8, 10, 11, 12, 15, 16, 17, 18, 19, 20, 24, 26, 28, 32, 33, 35, 41, 45, 46, 50, 51, 52, 53, 54, 56, 57, 58, 60, 61, 63, 64, 65, 67, 68, 69, 70, 71, 74, 75, 76, 78, 80, 81, 83], heavy metals [31, 36, 39, 58], also finding application in clinical and pre-clinical studies designed to assess the pharmacokinetic, bioequivalence and Absorption, Distribution, Metabolism and Excretion (ADME) of the formulations examined [1, 3, 5], also in order to characterize new delivery systems of the active principle [30, 44, 48, 72, 73] to improve their pharmacological properties. In the development of the method are applied predictive models and chemometric both for the optimisation of extraction protocols and for final data processing . Particular attention is given to the new instrument configurations for the quantitative analysis in complex matrix [9, 13, 14, 27, 34, 38, 40, 42, 43, 55, 79]. Scientific activity  was attested by publication on international journal, by oral and poster communication at international congress. Besides he is reviewer for international journals (alphabetical order): 1. Acta Chromatographica; 2. African Journal of Pharmacy and Pharmacology; 3. American Chemical Science Journal 4. American Journal of Modern Chromatography 5. Analytica Chimica Acta; 6. Analytical and Bioanalytical Chemistry; 7. Analytical Letters; 8. Bio Med Research International; 9. Bioorganic & Medicinal Chemistry; 10. British Journal of Medicine and Medical Research; 11. British Journal of Pharmaceutical Research; 12. Catalysis Letters; 13. Central European Journal of Chemistry; 14. Chemico-Biological Interactions 15. Chemistry Central Journal; 16. Chemosphere 17. Comprehensive Reviews in Food Science and Food Safety 18. Current Bioactive Compounds; 19. Current Organic Chemistry; 20. Czech Journal of Food Sciences; 21. Environmental Science & Technology; 22. Environmental Science and Pollution Research; 23. European Journal of Medicinal Plants; 24. Evidence-Based Complementary and Alternative Medicine. 25. Food & Function 26. Food Analytical Methods 27. Food and Chemical Toxicology, 28. Food Chemistry; 29. Global Journal of Analytical Chemistry; 30. Industrial & Engineering Chemical Research; 31. Industrial Crops and Products 32. Instrumentation Science & Technology; 33. International Journal Of Biochemistry Research & Review; 34. International Journal of Molecular Science; 35. International Journal of Nanomedicine 36. International Journal of pure and applied chemistry 37. Journal Of Advances In Biology & Biotechnology; 38. Journal of advances in medical and pharmaceutical Science; 39. Journal of Analytical Methods in Chemistry 40. Journal of Biology and Nature 41. Journal of Chemistry; 42. Journal of Chromatography A; 43. Journal of Chromatography B; 44. Journal of Enzyme Inhibition and Medicinal Chemistry; 45. Journal of Food Composition and Analysis; 46. Journal of Functional Foods; 47. Journal of Heterocyclic Chemistry 48. Journal of King Saud University; 49. Journal of Medicinal Plant Research 50. Journal of Pharmaceutical and Biomedical Análisis; 51. Journal of Polymers and the Environment 52. Journal of Separation Science; 53. Journal Of Taiwan Institute Of Chemical Engineers; 54. Medicinal Chemistry; 55. Mini-Review in Medicinal Chemistry; 56. Mini-Review in Organic Chemistry; 57. Molecules; 58. Natural Product Research; 59. Nature Protocols 60. Neuroscience 61. New Journal of Chemistry 62. Phytochemical Analysis; 63. Preparative Biochemistry and Biotechnology; 64. Talanta; 65. Trends in Analytical Chemistry;
He’s an External Expert in the remote evaluation of research projects for e-Cost (European Cooperation in Science & Technology). He’s a referee for MIUR Institution for National Projects (SIR), and introduced in the register REPRISE (Register of Expert Peer Reviewers for Italian Scientific Evaluation) in the "Basic Research" section. Referee for VQR 2011-2014. He’s referee for other universities of proposals through competitive tenders for the allocation of University funds for the activation of research grants (Università degli Studi dell'Insubria 2016, Università degli Studi di Firenze 2017).
He's member of the Editorial Board of the journal “Current Bioactive Compounds” (Bentham Science Publisher, ISSN: 1875-6646 Online, ISSN: 1573-4072 Print), “American Journal of Modern Chromatography” (Columbia International Publishing, ISSN: 2374-5479 Online), and “Journal of Selcuk University Science Faculty” (ISSN: 2458-9411). He is a member of the Scientific Committee of the journal "Science and Research", published by the Italian Association of the Book.
Editorial Board Memberships
Marcello is not currently contributing as an editor for any journal or publisher.
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