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Yossef Av-Gay

Bio

I am a microbiologist engaged in basic research mastering microbial genetics and biochemistry of microorganisms. My research focuses on translational research of bacterial pathogens aiming at anti microbial drug development. My first major contribution to the field of Tuberculosis (TB) research was the identification of the “Eukaryotic – like” protein kinases of Mycobacterium tuberculosis, a new family of proteins which play a role in the bacterial adaptive gene expression and cross-talk with the infected human macrophages. This discovery opened a new field of research into signaling elements of M. tuberculosis and gained my laboratory leading recognition in mycobacterial signal transduction research. In collaboration with industry my group has shown that small molecules targeted against one of these kinases can block the growth of M. tuberculosis within macrophages and thus can be used as novel anti-TB therapy. Using proteomics and global kinome analysis my team showed that mycobacterial infection triggers a signaling cascade leading to activation of stress-activated protein kinases. More recently, our research identified an M. tuberculosis Phosphatase, PtpA, which inhibits macrophage “normal” response to infection by targeting host signaling proteins and the macrophage acidification machinery. To show that we used gene knock-out and substrate trapping technologies and a novel technique, neutralizing PtpA in vivo by expressing intracellular single chain antibodies within the TB infected macrophage. My research into nitric oxide reveal its role in activating M. tuberculosis kinases and identified the thiol-based mechanism used by mycobacteria to protect themselves from nitric oxide damage. We have translated our basic research into commercialization by licensing his technologies to various companies.

Editorial Board Memberships
Current Memberships
Pre Publication Reviews

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Reviews

107

Reviews (last 12 months)

9

Reviews (average per year)

11

Merit

321

Openness

0.0%

Review to Publication ratio

1.2:1


Journal Impact Factors of journals reviewed for

The distribution of the Journal Impact Factors of journals Yossef Av-Gay has reviewed for.

Yossef Av-Gay

All fields reviewers

Total reviews over time

A cumulative record of Yossef Av-Gay's total number of reviews.

Reviews per month

The total number of reviews performed by Yossef Av-Gay each month.

Average review length

The average number of words per review compared to the average of All fields reviewers and the average of reviewers at affiliated institutions.

Note: only reviews with associated content are included in the graph below and where content is present we can not guarantee that it is complete or truly the content of the review.

Weekly review punchcard

The distribution of days that reviews were performed on, compared to All fields reviewers and reviewers at affiliated institutions.