My research interests include the role of the Ifi200-family genes in the development of autoimmunity, inflammation, and associated diseases. The family includes the interferon-inducible structurally-related murine and human genes. The murine genes (Ifi202a, Ifi202b, Ifi203, Mndal, and Aim2 etc.) form a cluster, which is located between the Spna-1 and the Sap loci on the long arm of Chromosome 1. The human genes (IFI16, MNDA, IFIX, and AIM2) are located in the syntenic 1q22 region. Proteins (the p200-proteins) encoded by the Ifi200-family genes share at least one partially conserved repeat of 200-amino acids (or HIN200 domain). Most proteins in the family also contain a homotypic protein-protein interaction pyrin domain (PYD). The PYD is often found in proteins that regulate a variety of physiologic responses, including cytokine responses and inflammation. The p200-family proteins mediate the biological and immunomodulatory activities of the IFNs. These activities include inhibition of cell cycle progression, modulation of autophagy and apoptosis, cellular senescence, and potentiation of cellular differentiation. Accumulating evidence indicates that the expression of some of the p200-family proteins is regulated by sex hormones. Alterations in the expression of the p200-family proteins are associated with the development of human autoimmune diseases and inflammation-associated diseases. Specifically, the laboratory is interested in investigating the role of the Aim2-like receptor (ALR) proteins and their inhibitors in autoimmunity. Additionally, the laboratory is investigating the role of ALR proteins in chronic inflammation-associated prostatic diseases.
I have served as an ad-hoc reviewer for a number of journals, including the Cancer Research, Molecular Cell Biology, Clinical Cancer Research, FEBS Letters, Oncogene, Journal of Biological Chemistry, Journal of Immunology, Leukemia, Journal of Cancer Research, Journal of Investigative Dermatology, and Molecular Cancer Therapeutics, Endocrine-Related Cancer, Experimental Cell Research, Journal of Cellular Biochemistry, International Journal of Cancer, Molecular Medicine, and Frontiers in Bioscience.
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