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Rajib Deb

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Dr. Rajib Deb, Scientist (Senior Scale), MVSc, PhD, ICAR-Central Institute for Research on Cattle, Meerut, UP, India has made outstanding contributions in advanced molecular biology and genetics research of livestock specially cattle, the prime animals in agriculture. His research reflects a continuum of high quality basic, strategic, and applied research in cattle health and productivity. Besides his research publications, he also contributed in several books from ICAR and other National sources. He has filed four patents and two under commercialization. He has received grants from SERB, DST, DBT as well as TWAS, Italy. Besides these he also received several national societies’ awards towards his research outputs. His major research contribution towards agriculture sectors are highlighted here- (i) Developed a LAMP assay for early detection of cow milk/meat adulterated in buffalo or goat counterparts, which is economical and user friendly (The Patent Office Journal 31/03/2017, Page No:8096; The Patent Office Journal 45/2017, Page No:39817; Mol Biotechnol. 2016 Dec; 58(12):850-860) (ii) Methodologies developed for user friendly tests for early detection of certain genetic disorders (BLAD and CVM) in breeding bulls prior to collection of germplasms (The Patent Office Journal 34/2017, Page No:27763;BMC Res Notes. 2018 Feb 15;11(1):132; Springerplus. 2016 Aug 30;5(1):1442) (iii) Artificial neural network based methodology developed for early prediction of bull semen post thaw motility which may reduce time and manpower (Theriogenology. 2015 Jun;83(9):1445-50) (iv) A Reverse transcriptase Loop Mediated Isothermal Amplification (RT-LAMP) assay was developed for profiling of heat shock proteins during cellular thermal stress in bovine species which is superior than normal Real Time PCR based assay in terms of time and costly equipments (Mol Biol Rep. 2017 Jul;44(3):281-287) (v) Discovered novel microRNAs (miRNAs) through NGS based analysis, which are directly or indirectly related to cellular thermotolerance in cattle (Cell Stress Chaperones. 2018 Jan;23(1):155-170) (vi) For the first time he identified that, Internal Ribosomal elements (IRES) at 5’ untranslated regions of bovine heat shock protein genes are functional, which may open a novel thermos regulatory mechanisms of animals during cellular thermal stress (Indian Patent filed with application number application number 201711042562 dated 28/11/2017) (vii) A Double PCR RFLP and ASPCR methodology was developed for identifying SNPs within different bovine heat shock protein genes which are associated with milk production or reproductive traits (Anim Biotechnol. 2015;26(1):45-50; Gene. 2013 Dec 15;532(2):230-5) (viii) Investigated that promoter variations at AP2 box region of bovine heat shock protein 70 may affect thermal stress response and milk production traits in bovine species (ix) Differential expression profiling of major stressor genes among indigenous and crossbred bovine species were investigated (J Therm Biol. 2016 Jul;59:18-25; Int J Biometeorol. 2017 May;61(5):931-941. doi: 10.1007/s00484-016-1273-1; Int J Biometeorol. 2015 Dec;59(12):1783-9; Gene. 2014 Feb 25;536(2):435-40) (x) Identified the docking site of integrin host receptor (bovine) for the RGD domain of VP1 protein of Foot-and -mouth disease virus and explore the causes of its genetic variability of host-viral interaction among different livestock species (Symposium on “Accelerating Biology 2015: catalyzing evolution” organized by the bioinformatics group of C-DAC, Pune from 20-22 January 2015 Pp.130-131) (xi) Tetra ARMS PCR based assays were developed for genetic screening of FMD Viral host receptor in cattle for identifying resistant or less susceptible animals (Adv Exp Med Biol. 2017 Jun 1. doi: 10.1007/5584_2017_47; Virus disease. 2015 Jun;26(1-2):48-54; Meta Gene. 2015 Jan 10;3:26-30; Arch Virol. 2014 Dec;159(12):3385-9) (xii) For the first time demonstrated the use of genotyping-by-sequencing (GBS) for a rapid inventory of the more than 100,000 SNPs in seven major Indian zebu cattle breeds which might prompt implementation of GBS in breeding policy of cattle belonging to this region (Animal Genetics. 2018. doi.10.1111/age.12650) (xiii) Functional proteomic profile of crossbred (Holstein Friesian X Sahiwal) bull spermatozoa was discovered which may be importance for identifying proteome biomarkers associated with fertility problems in cattle (xiv) First time seen that, genetic variation at OAS1 are associated with pregnancy, other reproductive performance and incidence of normal calving in indigenous and crossbred cattle (Theriogenology. 2018 Mar 1;108:255-261.; Reproduction in Domestic Animals. doi: 10.1111/rda.13129) (xv) Factor XI deficiency in Indian Sahiwal (Bos indicus) cattle bred was recorded for the first time, which may be include for genetic disease screening in Indian cattle breeds prior to germplasm distribution to stockholders (Mol Biol Rep. 2016 Apr;43(4):2

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