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David G. I. Kingston

Bio

David G. I. Kingston was born in London, UK, and received his B.A. degree in Natural Sciences in 1960 and his Ph.D. degree in 1964, both from Cambridge University; his Ph.D. advisors were the Nobel Laureate Lord Todd and Dr. D. W. Cameron. After postdoctoral appointments at M.I.T. and Cambridge, he moved to the U.S.A., where he is currently a University Distinguished Professor in the Department of Chemistry at Virginia Polytechnic Institute and State University (Virginia Tech). David studies natural products for medical usefulness, with cancer and malaria as particular targets. He was the principal investigator and group leader for biodiversity utilization and conservation projects in Suriname and in Madagascar. In addition to scientific discoveries of new bioactive natural products, this project assisted in the creation of the Central Suriname Nature Reserve and of new protected areas in Madagascar. He is currently examining the former Merck collection of natural product extracts now managed by the Natural Product Discovery Institute for antimalarial constituents. David also made significant contributions to the chemistry of paclitaxel, which is marketed as Taxol® and is widely used to treat breast and ovarian cancer; he was the first chemist in the United States to study the chemistry of this drug. He has prepared hundreds of derivatives of paclitaxel, including several with improved activity compared with the parent compound, and he has provided experimental confirmation of the proposed “T-taxol” tubulin-binding conformation of paclitaxel. A significant validation of this conformation was the synthesis of compounds that owe their improved activity to being constrained to the T-taxol conformation. He is currently working in drug delivery of paclitaxel using gold nanoparticles. David is the founding Director of the Virginia Tech Center for Drug Discovery, which has the aim of promoting drug discovery at Virginia Tech by fostering collaborations between chemists and biologists. He has received many honors and awards, including the Research Achievement Award of the American Society of Pharmacognosy in 1999, the Virginia Scientist of the Year Award in 2002, and the ACS Guenther Award in the Chemistry of Natural Products in 2008. In addition to his scientific work, David also serves as one of several lay pastors in his local church, the Blacksburg Christian Fellowship.

Research Fields

Chemical Sciences

Pre Publication Reviews

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Reviews

126

Reviews (last 12 months)

30

Reviews (average per year)

17

Merit

378

Openness

0.0%


Journal Impact Factors of journals reviewed for

The distribution of the Journal Impact Factors of journals David G. I. Kingston has reviewed for.

David G. I. Kingston

All fields reviewers

Total reviews over time

A cumulative record of David G. I. Kingston's total number of reviews.

Reviews per month

The total number of reviews performed by David G. I. Kingston each month.

Average review length

The average number of words per review compared to the average of All fields reviewers and the average of reviewers at affiliated institutions.

Note: only reviews with associated content are included in the graph below and where content is present we can not guarantee that it is complete or truly the content of the review.

Weekly review punchcard

The distribution of days that reviews were performed on, compared to All fields reviewers and reviewers at affiliated institutions.